Estimates the expected LDL-C at 3 months after a treatment change by back-calculating the untreated baseline LDL from the current regimen and applying the multiplicative reduction of the new regimen.
Method:
LDLbaseline = LDLcurrent / (1 − rcurrent) ·
LDLpredicted = LDLbaseline × (1 − rnew) ·
For combinations: rtotal = 1 − Π(1 − ri) ·
Reduction values from Law meta-analysis (BMJ 2003), ESC 2021 and PCSK9/inclisiran trials.
Current treatment Starting point
Regimen the patient is taking when the current LDL-C is measured.
Estimated combined reduction49%
Proposed treatment New regimen
Regimen to be started — predicted LDL is calculated at 8–12 weeks.
Estimated combined reduction55%
3-month prediction
Predicted LDL-C
132mg/dL
vs. target < 55 mg/dL · difference +77
Absolute change
−18mg/dL
≈ −12% vs. current
Estimated untreated baseline
294mg/dL
Back-calculated from current regimen
LDL-C trajectory
Est. baseline
294
Current
150
Predicted
132
Alternative regimens on the same patient
Predicted LDL-C if each of these options were started in place of the proposed regimen. Sorted by increasing potency.